Professional Info

Dr. Daniel J. Duke, PhD
ARC DECRA Fellow (2017)
Laboratory for Turbulence Research in Aerospace & Combustion
Department of Mechanical & Aerospace Engineering
Faculty of Engineering
Monash University, Australia

Qualifications

  • Ph.D. (Engineering, 2013)
  • Laboratory for Turbulence Research in Aerospace & Combustion
    Department of Mechanical & Aerospace Engineering
    Monash University Clayton Campus, Victoria, Australia
  • Bachelor of Engineering (Mechanical, 1st Class Honours)
    Bachelor of Technology (Aerospace)
    Monash University, 2007.

Research Areas

  • Fluid mechanics
  • Turbulence
  • Pharmaceutical sprays (aerosols and dry powder inhalers)
  • Fuel injection in gas turbine & internal combustion systems
  • Atomisation and spray formation
  • Multiphase flows
  • Hydrodynamic & aerodynamic instability
  • Optical diagnostic techniques
  • Synchrotron X-ray diagnostic techniques
    • Time resolved radiography
    • X-ray fluorescence spectroscopy
    • X-ray phase contrast imaging
    • Small angle x-ray scattering

Awards, Grants and Career Highlights

  • Linkage Project — Australian Research Council — 2017
    LP160101845 – “Improving respiratory drug delivery through targeted nozzle design”. Industry Partner – Chiesi Limited
    The project aims to develop designs for inhaler components which significantly reduce the existing variability in the sprays they produce, as well as an enhanced capacity to predict inhaler performance through development of new empirical models. This project will combine recently developed synchrotron x-ray measurement techniques with traditional visible light diagnostics to develop a greater understanding of the link between the geometry of pressurised, metered-dose inhaler components and the drug particles these devices produce. The long term benefit from this research will be improved delivery efficiency and shorter product development times, leading to reduced dose-rate costs. This understanding will enable the development of the next generation of treatment devices with enhanced efficiency in delivery of the drugs used to treat these diseases and reduced costs per dose.
  • Discovery Early Career Research Award — Australian Research Council — 2017
    DE170100018 – “Engineering suspended particle sprays through controlled cavitation”
    This project aims to establish how cavitation can be used to engineer particle size in sprays of micronised particles suspended in a propellant, and deliver a physical mechanism by which this process occurs. This will be achieved through a novel combination of high-resolution optical imaging techniques and synchrotron x-ray diagnostics. Understanding how cavitation affects the size of agglomerates in the liquid phase, and how it affects droplet size in a spray is critical to the development of spray devices that require precise control over the final particle size. This research will provide physical insight that will have applications for inhaled and topical pharmaceutical sprays, as well as industry spray drying of food products.
  • US Department of Energy Laboratory Directed Research & Development (LDRD) Seed Grant — 2016
    Grant 2017-098-N0 – “X-ray Investigation of the Potential of Pressure-Assisted Atomization Technology for Medical Inhaler Sprays.”
    Recieved USD 25.5k in funding from the U.S. Department of Energy to undertake a 6-month research project using synchrotron x-rays at the Advanced Photon Source at Argonne National Laboratory to investigate the commercial potential of pressure assisted atomization for pharmaceutical sprays.
  • Best Oral Presentation Award – ILASS-Europe conference — 2016
    Awarded by the committee of the 27th European Conference on Liquid Atomization and Spray Systems held in Brighton, UK, September 2016. Dr. Duke recieved the Best Oral Presentation award for his paper “Time-resolved x-ray radiography of cavitation in a metal nozzle.”
  • William R. Marshall Award — 2016
    Awarded by the Institute of Liquid Atomization and Spray Systems – North & South America, for the technical paper “String Flash-Boiling in Flashing and Non Flashing Gasoline Direction Injection Simulations with Transient Needle Motion,” which was judged the most significant contribution to the ILASS-Americas 28th Annual Conference in Dearborn, Michigan, May 2016.
  • Argonne National Laboratory “Pacesetter Award” — 2016
    Awarded by the Laboratory Director “for excellence in achievement and performance which truly surpasses normal job expectations.”
  • APS Highlights 2016 feature article and press release — 2016
    Work on medical sprays at Argonne’s Advanced Photon Source was featured in the APS highlights and in a press release which was featured on the US Department of Energy Office of Science web site.
  • Invited Speaker and Expert Panelist — 2016
    At the ILASS-Americas 28th Annual Conference on Liquid Atomization and Spray Systems internal nozzle flow workshop, May 2016, Mighigan, USA. Presenting alongside senior scientists from Sandia National Laboratories, Delphi Automotive, General Motors, Univ. Massachusetts-Amherst.
  • Invited Keynote Speaker — 2015
    “A Review of Synchrotron Radiation Diagnostics for Fluid Mechanics,” 7th Australian Conference on Laser Diagnostics in Fluid Mechanics and Combustion, Melbourne, Australia, December 2015.
  • Invited Speaker and Session Co-ordinator — 2015
    Presented on Gasoline Direct Injection internal and near-nozzle experiments at the 4th Engine Combustion Network Workshop, Kyoto, Japan, September 2015.
    ANSTO Fulbright Scholar in Nuclear Science & Technology — 2011
    12 month funded placement to the Advanced Photon Source at Argonne National Laboratory.
  • William R. Marshall Award — 2013
    Awarded by the Institute of Liquid Atomization and Spray Systems – North & South America, for the technical paper “Synchrotron X-ray Measurements of Cavitation,” which was judged the most significant contribution to the ILASS-Americas 25th Annual Conference in Pittsburgh, Pennsylvania, May 2013.
  • Advanced Photon Source General User Proposal Merit Allocation
    Lead investigator on five APS (synchrotron) general user proposals.
    Co-investigator on 13 additional user proposals since 2011.
  • Argonne Laboratory Computing Resource Center Grant — 2011 -2017
    Was principal investigator on a collaborative high performance computing grant of up to 1 million core-hours p.a. Research includes high-fidelity RANS and LES models of cavitating nozzle flow for liquid and gaseous fuel injection systems, and high-resolution x-ray tomographic reconstructions of fuel sprays.
  • Bill Melbourne Medal – 2012
    Award for Best Engineering PhD Thesis of 2012. Faculty of Engineering, Monash University, Australia.

Research Experience

  • Postdoctoral Appointee, Argonne National Laboratory, 2011— 2017
    • Applying x-ray diagnostics to fuel injection, sprays, and cavitation at the Advanced Photon Source
    • Spearheaded a collaborative research project using x-ray fluorescence spectroscopy and radiography to study spray and drug distribution in pressurized metered dose inhaler sprays.
    • Developed novel experiments to measure the quantitative distribution of cavitation vapor inside metal and plastic nozzles using x-ray fluorescence spectroscopy and radiography techniques. Lead a collaborative project to develop these experiments in line with state-of-the art models developed by academic partners.
    • Our team developed a novel approach to droplet size measurements in the dense core of a high-pressure diesel spray, using ultra-small-angle x-ray scattering.
    • Technical expertise in time-resolved x-ray computed tomography, x-ray radiography, x-ray phase contrast imaging, x-ray fluorescence spectroscopy and ultra-small angle x-ray scattering
.
  • Research Associate (Postdoctoral), Monash University, Australia, 2013
    • Development of high-speed backlit imaging experiments to measure the impact and break-up of solid drug particles from a powdered metered dose inhaler
    • Technical expertise in high speed imaging, planar particle image velocimetry, dynamic mode decomposition, proper orthogonal decomposition, high performance computing.
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